Palladium-catalyzed carbonylative cross-coupling with imines: A multicomponent synthesis of imidazolones

被引：48

作者：

Siamaki, Ali R. ^{[1
]}

Black, Daniel A. ^{[1
]}

Arndtsen, Bruce A. ^{[1
]}

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 03期

关键词：

D O I：

10.1021/jo701875b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The palladium-catalyzed coupling of imines, chloroformates, organotin reagents, and carbon monoxide leads to the one-pot formation of ketocarbamates in good yields. These products can further be converted to highly substituted imidazolones via a cyclocondensation reaction. Overall, this methodology provides an alternative approach to imidazolones from five simple and readily available building blocks via a one-pot, multicomponent process.

引用

页码：1135 / 1138

页数：4

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