A Molecular Leverage for Helicity Control and Helix Inversion

被引：107

作者：

Akine, Shigehisa ^{[1
]}

Hotate, Sayaka ^{[1
]}

Nabeshima, Tatsuya ^{[1
]}

机构：

[1] Univ Tsukuba, Grad Sch Pure & Appl Sci, Tsukuba, Ibaraki 3058571, Japan

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 35期

关键词：

DIAZA-COPE REARRANGEMENT; B DNA CONFORMATIONS; MACROMOLECULAR HELICITY; COBALT(II) COMPLEX; SENSE INVERSION; LANTHANIDE(III) COMPLEXES; ABIOTIC METALLOFOLDAMERS; ABSOLUTE HELICITY; COPPER-COMPLEXES; CHIRALITY;

D O I：

10.1021/ja205570z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The helical tetranuclear complex [LZn(3)La-(OAc)(3)] having two benzocrown moieties was designed and synthesized as a novel molecular leverage for helicity control and helix inversion. Short alkanediammonium guests H(3)N(+)-(CH(2))(n)NH(3)(+) (n = 4, 6, 8) preferentially stabilized the P-helical isomer of [LZn(3)La(OAc)(3)], while the longer guest H(3)N(+)(CH(2))(12)NH(3)(+) caused a helix inversion to give the M-helical isomer as the major isomer. The differences in the molecular lengths were efficiently translated into helical handedness via the novel molecular leverage mechanism using the gauche/anti conversion of the trans-1,2-disubstituted ethylenediamine unit.

引用

页码：13868 / 13871

页数：4

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