Minisci reactions: Versatile CH-functionalizations for medicinal chemists

被引:493
作者
Duncton, Matthew A. J. [1 ]
机构
[1] Renovis Inc, San Francisco, CA 94080 USA
关键词
ZENTRALNERVENSYSTEM WIRKENDE SUBSTANZEN; RAY-INDUCED REACTIONS; NUCLEIC-ACID CONSTITUENTS; SULFUR CHLORIDE PENTAFLUORIDE; COMPOSES HETEROAROMATIQUES AZOTES; INTRAMOLECULAR RADICAL ADDITIONS; HORMONE TRH ANALOGS; ANTITUMOR-ACTIVITY; DRUG DISCOVERY; ZUR CHEMIE;
D O I
10.1039/c1md00134e
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The addition of a radical to a heteroaromatic base is commonly referred to as a Minsici reaction. Such reactions constitute a broad-set of selective CH-functionalization processes. This review describes some of the major applications of Minisci reactions and related processes to medicinal or biological chemistry, and highlights some potential developments within this area.
引用
收藏
页码:1135 / 1161
页数:27
相关论文
共 241 条
  • [1] Adams D. R., 2000, Patent, Patent No. [WO2000012510, 20000012510]
  • [2] Practical synthesis of (S)-7-(2-isopropylamino)ethylcamptothecin hydrochloride, potent topoisomerase I inhibitor
    Ahn, SK
    Choi, NS
    Jeong, BS
    Kim, KK
    Journ, DJ
    Kim, JK
    Lee, SJ
    Kim, JW
    Hong, CI
    Jew, SS
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2000, 37 (05) : 1141 - 1144
  • [3] Bu3SnH-mediated radical cyclisation onto azoles
    Allin, Steven M.
    Barton, William R. S.
    Bowman, W. Russell
    Bridge nee Mann, Emma
    Elsegood, Mark R. J.
    McInally, Tom
    McKee, Vickie
    [J]. TETRAHEDRON, 2008, 64 (33) : 7745 - 7758
  • [4] Enthalpic and polar effects in the reactions of perfluoroalkyl radicals - New selective synthetic developments with alkenes and heteroaromatic bases
    Antonietti, F
    Mele, A
    Minisci, F
    Punta, C
    Recupero, F
    Fontana, F
    [J]. JOURNAL OF FLUORINE CHEMISTRY, 2004, 125 (02) : 205 - 211
  • [5] New, simple and selective synthesis of perfluoroalkylquinones by perfluoroalkyl radicals - Enthalpic and polar effects
    Antonietti, F
    Gambarotti, C
    Mele, A
    Minisci, F
    Paganelli, R
    Punta, C
    Recupero, F
    [J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2005, 2005 (20) : 4434 - 4440
  • [6] Synthesis and biodistribution of [11C]SN-38
    Apana, Scott M.
    Anderson, Lawrence W.
    Berridge, Marc S.
    [J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2010, 53 (3-4) : 178 - 182
  • [7] OXIDATIVE RADICAL CYCLIZATION OF (OMEGA-IODOALKYL)INDOLES AND PYRROLES - SYNTHESIS OF (-)-MONOMORINE AND 3 DIASTEREOMERS
    ARTIS, DR
    CHO, IS
    JAIMEFIGUEROA, S
    MUCHOWSKI, JM
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1994, 59 (09) : 2456 - 2466
  • [8] SYNTHESIS OF PERFLUOROALKYLPYRROLES BY HOMOLYTIC SUBSTITUTION WITH PERFLUOROALKYL RADICALS
    BACIOCCHI, E
    MURAGLIA, E
    [J]. TETRAHEDRON LETTERS, 1993, 34 (23) : 3799 - 3800
  • [9] HOMOLYTIC SUBSTITUTION-REACTIONS OF ELECTRON-RICH PENTATOMIC HETEROAROMATICS BY ELECTROPHILIC CARBON-CENTERED RADICALS - SYNTHESIS OF ALPHA-HETEROARYLACETIC ACIDS
    BACIOCCHI, E
    MURAGLIA, E
    SLEITER, G
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (25) : 6817 - 6820
  • [10] HOMOLYTIC AROMATIC SUBSTITUTIONS OF PENTATOMIC HETEROAROMATICS WITH ELECTROPHILIC CARBON RADICALS GENERATED BY ALKYL-HALIDES AND TRIETHYLBORANE
    BACIOCCHI, E
    MURAGLIA, E
    [J]. TETRAHEDRON LETTERS, 1993, 34 (31) : 5015 - 5018