Minisci reactions: Versatile CH-functionalizations for medicinal chemists

被引：493

作者：

Duncton, Matthew A. J. ^{[1
]}

机构：

[1] Renovis Inc, San Francisco, CA 94080 USA

来源：

MEDCHEMCOMM | 2011年 / 2卷 / 12期

关键词：

ZENTRALNERVENSYSTEM WIRKENDE SUBSTANZEN; RAY-INDUCED REACTIONS; NUCLEIC-ACID CONSTITUENTS; SULFUR CHLORIDE PENTAFLUORIDE; COMPOSES HETEROAROMATIQUES AZOTES; INTRAMOLECULAR RADICAL ADDITIONS; HORMONE TRH ANALOGS; ANTITUMOR-ACTIVITY; DRUG DISCOVERY; ZUR CHEMIE;

D O I：

10.1039/c1md00134e

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The addition of a radical to a heteroaromatic base is commonly referred to as a Minsici reaction. Such reactions constitute a broad-set of selective CH-functionalization processes. This review describes some of the major applications of Minisci reactions and related processes to medicinal or biological chemistry, and highlights some potential developments within this area.

引用

收藏

页码：1135 / 1161

页数：27

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