Copper-Catalyzed Aromatic Trifluoromethylation via Group Transfer from Fluoral Derivatives

被引：93

作者：

Kondo, Hideaki ^{[1
]}

Oishi, Masahiro ^{[1
]}

Fujikawa, Kenichi ^{[1
]}

Amii, Hideki ^{[1
,2
]}

机构：

[1] Kobe Univ, Grad Sch Sci, Dept Chem, Nada Ku, Kobe, Hyogo 6578501, Japan

[2] Gunma Univ, Grad Sch Engn, Dept Chem & Chem Biol, Gunma 3768515, Japan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2011年 / 353卷 / 08期

基金：

日本科学技术振兴机构;

关键词：

aromatic substitution; copper; cross-coupling; retro reactions; trifluoromethylation; NUCLEOPHILIC TRIFLUOROMETHYLATION; REDUCTIVE ELIMINATION; CONVENIENT METHOD; STABLE REAGENTS; ARYL HALIDES; C-C; PALLADIUM; BOND; PERFLUOROALKYL; REACTIVITY;

D O I：

10.1002/adsc.201000825

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Starting from a readily available fluoral derivative, catalytic aromatic trifluoromethylation has been successfully achieved. A small amount of copper(I) iodide-phenanthroline complex catalyzed the cross-coupling reactions of aryl/heteroaryl iodides with the O-silylated hemiaminal of fluoral (trifluoroacetaldehyde) to provide trifluoromethylated arenes in moderate to high yields.

引用

页码：1247 / 1252

页数：6

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