TET Family Proteins and Their Role in Stem Cell Differentiation and Transformation

被引：201

作者：

Cimmino, Luisa ^{[1
,2
]}

Abdel-Wahab, Omar ^{[3
,4
]}

Levine, Ross L. ^{[3
,4
]}

Aifantis, Iannis ^{[1
,2
]}

机构：

[1] New York Univ Sch Med, Howard Hughes Med Inst, New York, NY 10016 USA

[2] New York Univ Sch Med, Dept Pathol, New York, NY 10016 USA

[3] Mem Sloan Kettering Canc, Human Oncol & Pathogenesis Program, New York, NY 10016 USA

[4] Mem Sloan Kettering Canc, Dept Med, Leukemia Serv, New York, NY 10016 USA

来源：

CELL STEM CELL | 2011年 / 9卷 / 03期

基金：

澳大利亚国家健康与医学研究理事会; 美国国家卫生研究院;

关键词：

ACTIVE DNA DEMETHYLATION; ACUTE MYELOID-LEUKEMIA; PRIMORDIAL GERM-CELLS; CYTIDINE DEAMINASE AID; BASE EXCISION-REPAIR; SELF-RENEWAL; MYELODYSPLASTIC SYNDROMES; PATERNAL GENOME; GENE-EXPRESSION; IDH2; MUTATIONS;

D O I：

10.1016/j.stem.2011.08.007

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

One of the main regulators of gene expression during embryogenesis and stem cell differentiation is DNA methylaton. The recent identification of hydroxymethylcytosine (5hmC) as a novel epigenetic mark sparked an intense effort to characterize its specialized enzymatic machinery and to understand the biological significance of 5hmC. The recent discovery of recurrent deletions and somatic mutations in the TET gene family, which includes proteins that can hydroxylate methylcytosine (5mC), in a large fraction of myeloid malignancies further suggested a key role for dynamic DNA methylation changes in the regulation of stem cell differentiation and transformation.

引用

页码：193 / 204

页数：12

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