Assembly of the complete eight-base artificial genetic helix, xDNA, and its interaction with the natural genetic system

被引：79

作者：

Gao, JM ^{[1
]}

Liu, HB ^{[1
]}

Kool, ET ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 20期

关键词：

benzopurines; benzopyrimidines; DNA structures; nucleic acids; structure-activity relationships;

D O I：

10.1002/anie.200500069

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Expanding DNA: The four natural DNA nucleotides were combined with four benzo-homologous nucleotides to make self-assembling double helices (see base-paired structures). Strands of this "xDNA" form highly stable, sequence-specific duplexes with native DNA and RNA, and can expand the information capacity of DNA from a basis of four to eight characters. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：3118 / 3122

页数：5

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