Tec family kinases: regulation of FcεRI-mediated mast-cell activation

被引：42

作者：

Ellmeier, Wilfried ^{[1
]}

Abramova, Anastasia ^{[1
]}

Schebesta, Alexandra ^{[1
]}

机构：

[1] Med Univ Vienna, Inst Immunol, Div Immunobiol, Ctr Pathophysiol Infectiol & Immunol, A-1090 Vienna, Austria

来源：

FEBS JOURNAL | 2011年 / 278卷 / 12期

基金：

奥地利科学基金会;

关键词：

cytokine production; degranulation; early-phase and late-phase effector functions; Itk; mast cell signaling; Tec; TLR activation; type I hypersensitivity reactions; tyrosine kinases; BRUTONS-TYROSINE-KINASE; X-LINKED AGAMMAGLOBULINEMIA; T-LYMPHOCYTE DEVELOPMENT; BONE-MARROW; CYTOKINE PRODUCTION; SIGNALING PATHWAYS; ALLERGIC RESPONSES; HUMAN NEUTROPHILS; CROSS-LINKING; MICE LACKING;

D O I：

10.1111/j.1742-4658.2011.08073.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mast cells express the high-affinity receptor for IgE (Fc epsilon RI) and are key players in type I hypersensitivity reactions. They are critically involved in the development of allergic rhinitis, allergic asthma and systemic anaphylaxis, however, they also regulate normal physiological processes that link innate and adaptive immune responses. Thus, their activation has to be tightly controlled. One group of signaling molecules that are activated upon Fc epsilon RI stimulation is formed by Tec family kinases, and three members of this kinase family (Btk, Itk and Tec) are expressed in mast cells. Many studies have revealed important functions of Tec kinases in signaling pathways downstream of the antigen receptors in lymphocytes. This review summarizes the current knowledge about the function of Tec family kinases in Fc epsilon RI-mediated signaling pathways in mast cell.

引用

页码：1990 / 2000

页数：11

共 92 条

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