Branched RNA nanostructures for RNA interference

被引：45

作者：

Nakashima, Yuko ^{[1
,2
]}

Abe, Hiroshi ^{[1
]}

Abe, Naoko ^{[1
]}

Aikawa, Kyoko ^{[2
]}

Ito, Yoshihiro ^{[1
]}

机构：

[1] RIKEN, Adv Sci Inst, Nano Med Engn Lab, Wako, Saitama 3510198, Japan

[2] Ochanomizu Univ, Dept Chem, Fac Sci, Bunkyo Ku, Tokyo 1128610, Japan

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 29期

关键词：

DOUBLE-STRANDED-RNA; MAMMALIAN-CELLS; DNA; NANOTECHNOLOGY; POTENT; DICER;

D O I：

10.1039/c1cc11780g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Branched RNAs with three- or four-way junctions were designed by assembling single-stranded RNA for RNA interference. Human Dicer transformed branched RNAs into about 20 base pairs of double-stranded RNA, which is a standard siRNA species. Our tetramer design provides a potent silencing effect over a period of 5 days.

引用

页码：8367 / 8369

页数：3

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