A simple continuous flow microwave reactor

被引：114

作者：

Bagley, MC

Jenkins, RL

Lubinu, MC

Mason, C

Wood, R

机构：

[1] Cardiff Univ, Sch Chem, Cardiff CF10 3AT, S Glam, Wales

[2] AstraZeneca R&D, Macclesfield SK10 4TF, Cheshire, England

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 17期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1021/jo0510235

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] A new simple procedure for microwave-assisted organic synthesis under continuous flow processing has been developed for use in a monomodal microwave synthesizer with direct temperature control using the instrument's in-built IR sensor. This design makes optimum use of the standing wave cavity to improve the energy efficiency of microwave-assisted flow reactions.

引用

收藏

页码：7003 / 7006

页数：4

相关论文

共 54 条

[31] Design, synthesis, and pharmacological evaluation of new farnesyl protein transferase inhibitors [J].

Houssin, R ;

Pommery, J ;

Salaün, MC ;

Deweer, S ;

Goossens, JF ;

Chavatte, P ;

Hénichart, JP .

JOURNAL OF MEDICINAL CHEMISTRY, 2002, 45 (02) :533-536

[32]

Hughes DD, 2002, SYNLETT, P1332

[33]

HUGHES DL, 1993, ORG PREP PROCED INT, V25, P609

[34] Microwave-induced esterification using heterogeneous acid catalyst in a low dielectric constant medium [J].

Kabza, KG ;

Chapados, BR ;

Gestwicki, JE ;

McGrath, JL .

JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (04) :1210-1214

[35] Controlled microwave heating in modern organic synthesis [J].

Kappe, CO .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (46) :6250-6284

[36] Scaling up of dihydropyridine ester synthesis by using aqueous hydrotrope solutions in a continuous microwave reactor [J].

Khadilkar, BM ;

Madyar, VR .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2001, 5 (04) :452-455

[37]

Kuhnert N, 2002, ANGEW CHEM INT EDIT, V41, P1863, DOI 10.1002/1521-3773(20020603)41:11<1863::AID-ANIE1863>3.0.CO

[38]

2-L

[39] An assessment of the technique of simultaneous cooling in conjunction with microwave heating for organic synthesis [J].

Leadbeater, NE ;

Pillsbury, SJ ;

Shanahan, E ;

Williams, VA .

TETRAHEDRON, 2005, 61 (14) :3565-3585

[40] Microwave assisted organic synthesis -: a review [J].

Lidström, P ;

Tierney, J ;

Wathey, B ;

Westman, J .

TETRAHEDRON, 2001, 57 (45) :9225-9283

← 1 2 3 4 5 6 →