WRYamide, a NPY-based tripeptide that antagonizes feeding in rats

被引：4

作者：

Chance, WT

Tao, ZY

Sheriff, S

Balasubramaniam, A

机构：

[1] Univ Cincinnati, Med Ctr, Dept Surg, Cincinnati, OH 45267 USA

[2] Vet Adm Med Ctr, Med Res Serv, Cincinnati, OH 45220 USA

来源：

BRAIN RESEARCH | 1998年 / 803卷 / 1-2期

关键词：

anorexia; anti-obesity peptide; NPY; hypothalamus; schedule-feeding;

D O I：

10.1016/S0006-8993(98)00574-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Modifications of (D-Trp32) neuropeptide Y (NPY) led to the development of potential peptide-based lower molecular weight (500-800 Dal NPY feeding antagonists. One compound, WRYamide (N-Ac-Trp-Arg-Tyr-NH2), blocked NPY-induced feeding for 1 to 4 h when injected intrahypothalamically (i.h.t.) at 1 to 40 mu g. Schedule-induced feeding was also antagonized for up to 24 h by 20 mu g of WRYamide, i.h.t. Injection of 2.5 mg/kg (1 mg/rat) of WRYamide, i.v., also reduced significantly schedule-induced feeding for 4 h. A conditioned taste aversion could not be classically conditioned to saccharin using WRYamide as the unconditioned stimulus. These results may lead to the development of systemically active anti-obesity drugs. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：39 / 43

页数：5

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