IKK/NF-κB signaling: balancing life and death -: a new approach to cancer therapy

被引：725

作者：

Luo, JL ^{[1
]}

Kamata, H ^{[1
]}

Karin, M ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Lab Gene Regulat & Signal Transduct, Dept Pharmacol & Canc Ctr, La Jolla, CA 92093 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 10期

关键词：

D O I：

10.1172/JCI26322

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

1KB kinase/NF-KB (IkK/NF-KB) signaling pathways play critical roles in a variety of physiological and pathological processes. One function of NF-KB is promotion of cell survival through induction of target genes, whose products inhibit components of the apoptotic machinery in normal and cancerous cells. NF-KB can also prevent programmed necrosis by inducing genes encoding antioxidant proteins. Regardless of mechanism, many cancer cells, of either epithelial or hematopoietic origin. use NF-KB to achieve resistance to anticancer drugs, radiation, and death cytokines. Hence, inhibition of IKK-driven NF-KB activation offers a strategy for treatment of different malignancies and can convert inflammation-induced tumor growth to inflammation-induced tumor regression.

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收藏

页码：2625 / 2632

页数：8

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