IKK/NF-κB signaling: balancing life and death -: a new approach to cancer therapy

被引:725
作者
Luo, JL [1 ]
Kamata, H [1 ]
Karin, M [1 ]
机构
[1] Univ Calif San Diego, Sch Med, Lab Gene Regulat & Signal Transduct, Dept Pharmacol & Canc Ctr, La Jolla, CA 92093 USA
关键词
D O I
10.1172/JCI26322
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
1KB kinase/NF-KB (IkK/NF-KB) signaling pathways play critical roles in a variety of physiological and pathological processes. One function of NF-KB is promotion of cell survival through induction of target genes, whose products inhibit components of the apoptotic machinery in normal and cancerous cells. NF-KB can also prevent programmed necrosis by inducing genes encoding antioxidant proteins. Regardless of mechanism, many cancer cells, of either epithelial or hematopoietic origin. use NF-KB to achieve resistance to anticancer drugs, radiation, and death cytokines. Hence, inhibition of IKK-driven NF-KB activation offers a strategy for treatment of different malignancies and can convert inflammation-induced tumor growth to inflammation-induced tumor regression.
引用
收藏
页码:2625 / 2632
页数:8
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