Novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella verrucosa

被引：72

作者：

Aiello, A

D'Esposito, M

Fattorusso, E

Menna, M

Müller, WEG

Perovic-Ottstadt, S

Schröder, HC

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] Univ Mainz, Inst Physiol Chem, Angew Mol Biol Abt, D-55099 Mainz, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 01期

关键词：

marine sponges; natural products; bromopyrrole alkaloids; Axinella verrucosa; neuroprotective activity;

D O I：

10.1016/j.bmc.2005.07.057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Mediterranean sponge Axinella verrucosa has been investigated for its alkaloid composition and has been found to produce a complex mixture of bromopyrrole alkaloids. Along with the previously isolated compounds 5-18, four novel alkaloids of this class, Compounds 1-4, have been isolated, and their Structures established through spectroscopic methods. Compounds 1-4 were found to display neuroprotective activity against the agonists scrotonin and glutamate in vitro. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：17 / 24

页数：8

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[1] Molecular mechanisms underlying specificity of excitotoxic signaling in neurons [J].