共 76 条
Small animal computed tomography Imaging
被引:48
作者:
Bartling, Soenke H.
Stiller, Wolfram
Semmler, Wolfhard
Kiessling, Fabian
机构:
[1] Deutsch Krebsforschungszentrum, Mol Imaging Grp, Dept Med Phys Radiol, D-69120 Heidelberg, Germany
[2] Deutsch Krebsforschungszentrum, Jr Grp Mol Imaging, D-69120 Heidelberg, Germany
关键词:
small animal imaging;
Computed Tomography (CT);
micro-CT;
mini-CT;
flat-panel detector;
motion gating;
D O I:
10.2174/157340507779940327
中图分类号:
R8 [特种医学];
R445 [影像诊断学];
学科分类号:
1002 ;
100207 ;
1009 ;
摘要:
Micro Computed Tomography (micro-CT) was suggested in biomedical research to investigate tissues and small animals. Its use to characterize bone structures. vessels (e.g. tumor vascularization), tumors and soft tissues such as lung parenchyma has been shown. When co-registered, micro-CT can add structural information to other small animal imaging modalities. However, due to fundamental CT principles, high-resolution imaging with micro-CT demands for high x-ray doses and long scan times to generate a sufficiently high signal-to-noise ratio. Long scan times in turn make the use of extravascular contrast agents difficult. Recently introduced flat-panel based mini-CT systems offer a valuable trade-off between resolution (similar to 200 mu m), scan time (0.5 s), applied x-ray dose and scan field-of-view. This allows for angiography scans and follow-up examinations using iodinated contrast agents having a similar performance compared to patient scans. Furthermore, dynamic examinations such as perfusion studies as well as retrospective motion gating are currently implemented using flat-panel CT. This review summarizes applications of experimental CT in basic research and provides an overview of current hardware developments making CT a powerful toot to stud), tissue morphology and function in small laboratory animals such as rodents.
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页码:45 / 59
页数:15
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