Small animal computed tomography Imaging

被引:48
作者
Bartling, Soenke H.
Stiller, Wolfram
Semmler, Wolfhard
Kiessling, Fabian
机构
[1] Deutsch Krebsforschungszentrum, Mol Imaging Grp, Dept Med Phys Radiol, D-69120 Heidelberg, Germany
[2] Deutsch Krebsforschungszentrum, Jr Grp Mol Imaging, D-69120 Heidelberg, Germany
关键词
small animal imaging; Computed Tomography (CT); micro-CT; mini-CT; flat-panel detector; motion gating;
D O I
10.2174/157340507779940327
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Micro Computed Tomography (micro-CT) was suggested in biomedical research to investigate tissues and small animals. Its use to characterize bone structures. vessels (e.g. tumor vascularization), tumors and soft tissues such as lung parenchyma has been shown. When co-registered, micro-CT can add structural information to other small animal imaging modalities. However, due to fundamental CT principles, high-resolution imaging with micro-CT demands for high x-ray doses and long scan times to generate a sufficiently high signal-to-noise ratio. Long scan times in turn make the use of extravascular contrast agents difficult. Recently introduced flat-panel based mini-CT systems offer a valuable trade-off between resolution (similar to 200 mu m), scan time (0.5 s), applied x-ray dose and scan field-of-view. This allows for angiography scans and follow-up examinations using iodinated contrast agents having a similar performance compared to patient scans. Furthermore, dynamic examinations such as perfusion studies as well as retrospective motion gating are currently implemented using flat-panel CT. This review summarizes applications of experimental CT in basic research and provides an overview of current hardware developments making CT a powerful toot to stud), tissue morphology and function in small laboratory animals such as rodents.
引用
收藏
页码:45 / 59
页数:15
相关论文
共 76 条
[61]   LATE EFFECTS OF WHOLE OR PARTIAL BODY X-IRRADIATION ON MICE - LIFE SHORTENING [J].
SATO, F ;
SASAKI, S ;
KAWASHIMA, N ;
CHINO, F .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1981, 39 (06) :607-615
[62]   A ghost story: Spatio-temporal response characteristics of an indirect-detection flat-panel imager [J].
Siewerdsen, JH ;
Jaffray, DA .
MEDICAL PHYSICS, 1999, 26 (08) :1624-1641
[63]   Cone-beam computed tomography with a flat-panel imager: Effects of image lag [J].
Siewerdsen, JH ;
Jaffray, DA .
MEDICAL PHYSICS, 1999, 26 (12) :2635-2647
[64]   The influence of antiscatter grids on soft-tissue detectability in cone-beam computed tomography with flat-panel detectors [J].
Siewerdsen, JH ;
Moseley, DJ ;
Bakhtiar, B ;
Richard, S ;
Jaffray, DA .
MEDICAL PHYSICS, 2004, 31 (12) :3506-3520
[65]   Three-dimensional trabecular bone architecture of the lumbar spine in bone metastasis from prostate cancer: comparison with degenerative sclerosis [J].
Tamada, T ;
Sone, T ;
Jo, Y ;
Imai, S ;
Kajihara, Y ;
Fukunaga, M .
SKELETAL RADIOLOGY, 2005, 34 (03) :149-155
[66]   Monte Carlo simulations of dose from microCT imaging procedures in a realistic mouse phantom [J].
Taschereau, R ;
Chow, PL ;
Chatziioannou, AF .
MEDICAL PHYSICS, 2006, 33 (01) :216-224
[67]   CT visualization of blood pool in rats by using long-circulating, iodine-containing micelles [J].
Torchilin, VP ;
Frank-Kamenetsky, MD ;
Wolf, GL .
ACADEMIC RADIOLOGY, 1999, 6 (01) :61-65
[68]   PET, CT, and MR image registration of the rat brain and skull [J].
Vaquero, JJ ;
Desco, M ;
Pascau, J ;
Santos, A ;
Lee, I ;
Seidel, J ;
Green, MV .
IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 2001, 48 (04) :1440-1445
[69]   A molecular CT blood pool contrast agent [J].
Vera, DR ;
Mattrey, RF .
ACADEMIC RADIOLOGY, 2002, 9 (07) :784-792
[70]   Dose reduction in skeletal and chest radiography using a large-area flat-panel detector based on amorphous silicon and thallium-doped cesium iodide:: technical background, basic image quality parameters, and review of the literature [J].
Völk, M ;
Hamer, OW ;
Feuerbach, S ;
Strotzer, M .
EUROPEAN RADIOLOGY, 2004, 14 (05) :827-834