The Arabidopsis thaliana ethylene-responsive element binding protein (AtEBP) can function as a dominant suppressor of Bax-induced cell death of yeast

被引：35

作者：

Pan, L ^{[1
]}

Kawai, M ^{[1
]}

Yu, LH ^{[1
]}

Kim, KM ^{[1
]}

Hirata, A ^{[1
]}

Umeda, M ^{[1
]}

Uchimiya, H ^{[1
]}

机构：

[1] Univ Tokyo, Inst Mol & Cellular Biosci, Bunkyo Ku, Tokyo 1130032, Japan

来源：

FEBS LETTERS | 2001年 / 508卷 / 03期

基金：

日本学术振兴会;

关键词：

Arabidopsis thaliana ethylene-responsive element binding protein; Bax; cell death; yeast; Arabidopsis;

D O I：

10.1016/S0014-5793(01)03098-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We identified genes based on screening of an Arabidopsis cDNA library for functional suppressors of mouse Bax-induced cell death of yeast cells. Interestingly, the cDNA encoding AtEBP, known as Arabidopsis thaliana ethylene-responsive element binding protein, was isolated numerous times in the functional screen (82% of all suppressors). Full-length AtEBP and its localization to the nucleus were essential for the suppression of Bax-induced cell death. Morphological abnormality of intracellular network that is a hallmark of Bax-induced cell death was attenuated by expression of AtEBP. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：375 / 378

页数：4

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