Synthesis and cellular uptake of porphyrin decorated iron oxide nanoparticles - a potential candidate for bimodal anticancer therapy

被引：159

作者：

Gu, HW

Xu, KM

Yang, ZM

Chang, CK

Xu, B

机构：

[1] Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong, Hong Kong, Peoples R China

[2] Hong Kong Univ Sci & Technol, Bioengn Program, Hong Kong, Hong Kong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2005年 / 34期

关键词：

D O I：

10.1039/b507779f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This paper reports the synthesis, characterization, and cellular uptake of the conjugate of porphyrin and iron oxide nanoparticles, which may lead to a bimodal anticancer agent that can be used in the combinational treatment of photodynamic therapy (PDT) and hyperthermia therapy (HT).

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收藏

页码：4270 / 4272

页数：3

相关论文

共 29 条

[11]

Ojima I., 2001, Anticancer Agents: Frontiers in Cancer Chemotherapy

[12]

Pandey RK, 1996, J MOL RECOGNIT, V9, P118

[13] Ultra-large-scale syntheses of monodisperse nanocrystals [J].

Park, J ;

An, KJ ;

Hwang, YS ;

Park, JG ;

Noh, HJ ;

Kim, JY ;

Park, JH ;

Hwang, NM ;

Hyeon, T .

NATURE MATERIALS, 2004, 3 (12) :891-895

[14] Synthesis and magnetic studies of uniform iron nanorods and nanospheres [J].

Park, SJ ;

Kim, S ;

Lee, S ;

Khim, ZG ;

Char, K ;

Hyeon, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (35) :8581-8582

[15] Preparation of magnetite nanoparticles in mesoporous copolymer template [J].

Rabelo, D ;

Lima, ECD ;

Reis, AC ;

Nunes, WC ;

Novak, MA ;

Garg, VK ;

Oliveira, AC ;

Morais, PC .

NANO LETTERS, 2001, 1 (02) :105-108

[16] Surface restructuring of nanoparticles: An efficient route for ligand-metal oxide crosstalk [J].

Rajh, T ;

Chen, LX ;

Lukas, K ;

Liu, T ;

Thurnauer, MC ;

Tiede, DM .

JOURNAL OF PHYSICAL CHEMISTRY B, 2002, 106 (41) :10543-10552

[17] Charge transfer across the nanocrystalline-DNA interface: Probing DNA recognition [J].

Rajh, T ;

Saponjic, Z ;

Liu, JQ ;

Dimitrijevic, NM ;

Scherer, NF ;

Vega-Arroyo, M ;

Zapol, P ;

Curtiss, LA ;

Thurnauer, MC .

NANO LETTERS, 2004, 4 (06) :1017-1023

[18] HYPERTHERMIA INDUCES APOPTOSIS IN THYMOCYTES [J].

SELLINS, KS ;

COHEN, JJ .

RADIATION RESEARCH, 1991, 126 (01) :88-95

[19] Porphyrin-based photosensitizers for use in photodynamic therapy [J].

Sternberg, ED ;

Dolphin, D ;

Brückner, C .

TETRAHEDRON, 1998, 54 (17) :4151-4202

[20] LONG CIRCULATING MICROPARTICULATE DRUG CARRIERS [J].

STOLNIK, S ;

ILLUM, L ;

DAVIS, SS .

ADVANCED DRUG DELIVERY REVIEWS, 1995, 16 (2-3) :195-214