New and efficient synthesis of 5′-amino-5′-(S)-methyl-2′,5′-dideoxynucleosides

被引：16

作者：

Jung, PMJ ^{[1
]}

Beaudegnies, R ^{[1
]}

De Mesmaeker, A ^{[1
]}

Wendeborn, S ^{[1
]}

机构：

[1] Syngenta Crop Protect AG, CH-4002 Basel, Switzerland

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 02期

关键词：

5 '-amino-5 '-(S)-methyl-2 '; 5 '-dideoxynucleosides; tert-butylsulfinamide; nucleophilic addition;

D O I：

10.1016/S0040-4039(02)02514-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short, efficient synthesis of 5'-amino-5'-(S)-methyl-2',5'-dideoxynucleosides 1 has been developed through the diastereoselective addition of methylmagnesium bromide or methyllithium to an intermediate tert-butylsulfinimide. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：293 / 297

页数：5

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