Amide backbone modifications for antisense oligonucleotides carrying potential intercalating substituents: Influence on the thermodynamic stability of the corresponding duplexes with RNA- and DNA-complements

被引：4

作者：

DeMesmaeker, A

Wendeborn, S

Jouanno, C

Fritsch, V

Wolf, RM

机构：

[1] Central Research Laboratories, CIBA-GEIGY Ltd.

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(97)00318-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of the amide dimers 3-5 carrying a potential intercalating substituent on the nitrogen atom of the backbone is presented, together with the incorporation of these modifications into oligonucleotides, the resulting melting temperatures (T-m's) of the corresponding duplexes with RNA- and DNA- complements and a summary of molecular modeling studies. (C) 1997 Elsevier Science Ltd.

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收藏

页码：1869 / 1874

页数：6

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