Whispering gallery mode bio-sensor for label-free detection of single molecules: thermo-optic vs. reactive mechanism

被引：85

作者：

Arnold, S. ^{[1
]}

Shopova, S. I. ^{[1
]}

Holler, S. ^{[2
]}

机构：

[1] NYU, Polytech Inst, MicroParticle PhotoPhys Lab, Brooklyn, NY 11201 USA

[2] Novawave Technol, Redwood Shores, CA 94065 USA

来源：

OPTICS EXPRESS | 2010年 / 18卷 / 01期

基金：

美国国家科学基金会;

关键词：

SHIFT;

D O I：

10.1364/OE.18.000281

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Thermo-optic and reactive mechanisms for label-free sensing of bio-particles are compared theoretically for Whispering Gallery Mode (WGM) resonators (sphere, toroid) formed from silica and stimulated into a first order equatorial mode. Although it has been expected that a thermooptic mechanism should "greatly enhance" wavelength shift signals [A.M. Armani et al, Science 317, 783-787 (2007)] accompanying protein binding on a silica WGM cavity having high Q (10(8)), for a combination of wavelength (680 nm), drive power (1 mW), and cavity size (43 mu m radius), our calculations find no such enhancement. The possible reasons for this disparity are discussed. (C) 2009 Optical Society of America

引用

页码：281 / 287

页数：7

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