Three new tricyclic guanidine alkaloids from the sponge Batzella sp.

被引：32

作者：

Patil, AD

Freyer, AJ

Offen, P

Bean, MF

Johnson, RK

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,RES & DEV,DEPT BIOMOL DISCOVERY,KING OF PRUSSIA,PA 19406

[2] SMITHKLINE BEECHAM PHARMACEUT,RES & DEV,DEPT ANALYT SCI,KING OF PRUSSIA,PA 19406

[3] SMITHKLINE BEECHAM PHARMACEUT,RES & DEV,DEPT PHYS & STRUCT CHEM,KING OF PRUSSIA,PA 19406

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 07期

关键词：

D O I：

10.1021/np970014r

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

During the large-scale isolation of the batzelladines A and B, which are inhibitors of gp120-CD4 binding, we isolated 19 minor guanidine alkaloids. Three new tricyclic guanidine alkaloids isolated from this group were named 8a,8b-dehydroptilocaulin (2), 8a,8b-dehydro-8-hydroxyptilocaulin (3), and 1,8a;8b,3a-didehydro-8-hydroxyptilocaulin (5). The recently described mirabilin B (4) was also isolated. The structures and relative stereochemistry of these compounds were determined by spectral analysis and by comparison with spectral data of ptilocaulin (1).

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页码：704 / 707

页数：4

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