Enzymatic Manipulation of DNA-Modified Gold Nanoparticles for Screening G-Quadruplex Ligands and Evaluating Selectivities

被引：38

作者：

Chen, Cuie ^{[1
,2
]}

Zhao, Chuanqi ^{[1
,2
]}

Yang, Xinjian ^{[1
,2
]}

Ren, Jinsong ^{[1
,2
]}

Qu, Xiaogang ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Rare Earth Chem & Phys, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China

来源：

ADVANCED MATERIALS | 2010年 / 22卷 / 03期

基金：

中国国家自然科学基金;

关键词：

COLORIMETRIC BIOSENSORS; TELOMERASE; ASSAY; APTAMER; INHIBITION; NANOWIRES;

D O I：

10.1002/adma.200901924

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enzymatic manipulation of DNA on well-dispersed gold nanoparticles (AuNPs) offers an ideal system for high-throughput screening of G-quadruplex ligands and evaluation of their selectivity with respect to duplex and quadruplex DNA (see figure). This work has implications for the future use of nanoparticle-based technologies in the discovery of potential cancer therapeutic agents.

引用

页码：389 / +

页数：6

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