Smaller and faster:: The 20-residue Trp-cage protein folds in 4 μs

被引：293

作者：

Qiu, LL ^{[1
]}

Pabit, SA ^{[1
]}

Roitberg, AE ^{[1
]}

Hagen, SJ ^{[1
]}

机构：

[1] Univ Florida, Dept Phys, Chem Dept & Quantum Theory Project, Gainesville, FL 32611 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 44期

关键词：

D O I：

10.1021/ja0279141

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We have used laser temperature jump spectroscopy to measure the folding speed of the 20-residue Trp-cage, the smallest polypeptide known to exhibit truly cooperative folding behavior. The observed folding time (4 μs at room temperature) makes this not only the smallest foldable protein, but also the fastest, with a folding speed that exceeds contact-order predictions and approaches anticipated diffusional "speed limits" for protein folding. Copyright © 2002 American Chemical Society.

引用

页码：12952 / 12953

页数：2

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