Synthesis of enantiomerically pure 4-aryl-3,4-dihydro-pyrimidin-2(1H)-ones via enzymatic resolution:: preparation of the antihypertensive agent (R)-SQ 32926

被引：62

作者：

Schnell, B ^{[1
]}

Strauss, UT ^{[1
]}

Verdino, P ^{[1
]}

Faber, K ^{[1
]}

Kappe, CO ^{[1
]}

机构：

[1] Karl Franzens Univ Graz, Inst Chem, A-8010 Graz, Austria

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 07期

基金：

奥地利科学基金会;

关键词：

D O I：

10.1016/S0957-4166(00)00081-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A practical and short synthesis of the enantiomerically pure dihydropyrimidone antitypertensive agent (R)-SQ 32926 has been developed. The key step in the synthesis is the enzymatic resolution of an N3-acetoxymethyl-activated dihdropyrimidone precursor by Thermomyces lanuginosus lipase. The absolute configuration of (R)-SQ 32926 was confirmed by circular dichroism spectroscopy. (C) Elsevier Science Ltd. All rights reserved.

引用

页码：1449 / 1453

页数：5

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