Specification and connectivity of neuronal subtypes in the sensory lineage

被引:288
作者
Marmigere, Frederic [1 ]
Ernfors, Patrik [1 ]
机构
[1] Karolinska Inst, Mol Neurobiol Sect, MBB, S-17177 Stockholm, Sweden
关键词
D O I
10.1038/nrn2057
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
During the development of the nervous system, many different types of neuron are produced. As well as forming the correct type of neuron, each must also establish precise connections. Recent findings show that, because of shared gene programmes, neuronal identity is intimately linked to and coordinated with axonal behaviour. Peripheral sensory neurons provide an excellent system in which to study these interactions. This review examines how neuronal diversity is created in the PNS and describes proteins that help to direct the diversity of neuronal subtypes, cell survival, axonal growth and the establishment of central patterns of modality-specific connections.
引用
收藏
页码:114 / 127
页数:14
相关论文
共 167 条
[91]   Structure and regulated expression of mammalian RUNX genes [J].
Levanon, D ;
Groner, Y .
ONCOGENE, 2004, 23 (24) :4211-4219
[92]   Causal relationship between the loss of RUNX3 expression and gastric cancer [J].
Li, QL ;
Ito, K ;
Sakakura, C ;
Fukamachi, H ;
Inoue, K ;
Chi, XZ ;
Lee, KY ;
Nomura, S ;
Lee, CW ;
Han, SB ;
Kim, HM ;
Kim, WJ ;
Yamamoto, H ;
Yamashita, N ;
Yano, T ;
Ikeda, T ;
Itohara, S ;
Inazawa, J ;
Abe, T ;
Hagiwara, A ;
Yamagishi, H ;
Ooe, A ;
Kaneda, A ;
Sugimura, T ;
Ushijima, T ;
Bae, SC ;
Ito, Y .
CELL, 2002, 109 (01) :113-124
[93]   Disruption of Smad5 gene leads to enhanced proliferation of high-proliferative potential precursors during embryonic hematopoiesis [J].
Liu, B ;
Sun, YX ;
Jiang, FZ ;
Zhang, SX ;
Wu, Y ;
Lan, Y ;
Yang, X ;
Mao, N .
BLOOD, 2003, 101 (01) :124-133
[94]   SENSORY BUT NOT MOTOR-NEURON DEFICITS IN MICE LACKING NT4 AND BDNF [J].
LIU, X ;
ERNFORS, P ;
WU, H ;
JAENISCH, R .
NATURE, 1995, 375 (6528) :238-241
[95]  
Lo LC, 2002, DEVELOPMENT, V129, P1553
[96]   Role of the transcription factor AML-1 in acute leukemia and hematopoietic differentiation [J].
Lutterbach, B ;
Hiebert, SW .
GENE, 2000, 245 (02) :223-235
[97]  
Ma L, 2000, DEVELOPMENT, V127, P3777
[98]   Brn3a regulation of TrkA/NGF receptor expression in developing sensory neurons [J].
Ma, L ;
Lei, L ;
Eng, R ;
Turner, E ;
Parada, LF .
DEVELOPMENT, 2003, 130 (15) :3525-3534
[99]   NEUROGENIN1 and NEUROGENIN2 control two distinct waves of neurogenesis in developing dorsal root ganglia [J].
Ma, QF ;
Fode, C ;
Guillemot, F ;
Anderson, DJ .
GENES & DEVELOPMENT, 1999, 13 (13) :1717-1728
[100]   The Runx1/AML1 transcription factor selectively regulates development and survival of TrkA nociceptive sensory neurons [J].
Marmigère, F ;
Montelius, A ;
Wegner, M ;
Groner, Y ;
Reichardt, LF ;
Ernfors, P .
NATURE NEUROSCIENCE, 2006, 9 (02) :180-187