A nanocatalyst-based assay for proteins:: DNA-free ultrasensitive electrochemical detection using catalytic reduction of p-nitrophenol by gold-nanoparticle labels

被引：276

作者：

Das, Jagotamoy ^{[1
]}

Aziz, Md. Abdul ^{[1
]}

Yang, Haesik ^{[1
]}

机构：

[1] Pusan Natl Univ, Dept Chem, Pusan 609735, South Korea

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 50期

关键词：

D O I：

10.1021/ja0672167

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This communication reports a nanocatalyst-based electrochemical assay for proteins. Ultrasensitive detection has been achieved by signal amplification combined with noise reduction: the signal is amplified both by the catalytic reduction of p-nitrophenol to p-aminophenol by gold-nanocatalyst labels and by the chemical reduction of p-quinone imine to p-aminophenol by NaBH4; the noise is reduced by employing an indium tin oxide electrode modified with a ferrocenyl-tethered dendrimer and a hydrophilic immunosensing layer. Copyright © 2006 American Chemical Society.

引用

页码：16022 / 16023

页数：2

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