Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer

被引：255

作者：

Ciardiello, Chiara ^{[1
,2
,3
,4
]}

Cavallini, Lorenzo ^{[1
,2
,3
,5
]}

Spinelli, Cristiana ^{[1
,2
,3
]}

Yang, Julie ^{[1
,2
,3
]}

Reis-Sobreiro, Mariana ^{[1
,2
,3
]}

de Candia, Paola ^{[6
]}

Minciacchi, Valentina Rene ^{[1
,2
,3
]}

Di Vizio, Dolores ^{[1
,2
,3
,7
,8
]}

机构：

[1] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Dept Surg, Div Canc Biol & Therapeut, Los Angeles, CA 90048 USA

[2] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Dept Biomed Sci, Los Angeles, CA 90048 USA

[3] Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Dept Pathol & Lab Med, Los Angeles, CA 90048 USA

[4] IRCCS Ist Nazl Tumori Fdn G Pascale, Dept Res, Expt Pharmacol Unit, I-80131 Naples, Italy

[5] Univ Florence, Dept Expt & Clin Biomed Sci, I-50121 Florence, Italy

[6] Ist Nazl Genet Mol Romeo & Enrica Invernizzi, I-20122 Milan, Italy

[7] Boston Childrens Hosp, Urol Dis Res Ctr, Boston, MA 02115 USA

[8] Harvard Univ, Sch Med, Dept Surg, Boston, MA 02115 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2016年 / 17卷 / 02期

基金：

美国国家卫生研究院;

关键词：

extracellular vesicles; exosomes; ectosomes; large oncosomes; microvesicles; cancer; intercellular communication; tumor microenvironment; MESENCHYMAL STEM-CELLS; LARGE ONCOSOMES; P-GLYCOPROTEIN; INTERCELLULAR TRANSFER; PROMOTE ANGIOGENESIS; PROTEOMICS ANALYSIS; MEMBRANE-VESICLES; MEDIATED TRANSFER; APOPTOTIC BODIES; TUMOR-CELLS;

D O I：

10.3390/ijms17020175

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Extracellular Vesicles (EVs) have received considerable attention in recent years, both as mediators of intercellular communication pathways that lead to tumor progression, and as potential sources for discovery of novel cancer biomarkers. For many years, research on EVs has mainly investigated either the mechanism of biogenesis and cargo selection and incorporation, or the methods of EV isolation from available body fluids for biomarker discovery. Recent studies have highlighted the existence of different populations of cancer-derived EVs, with distinct molecular cargo, thus pointing to the possibility that the various EV populations might play diverse roles in cancer and that this does not happen randomly. However, data attributing cancer specific intercellular functions to given populations of EVs are still limited. A deeper functional, biochemical and molecular characterization of the various EV classes might identify more selective clinical markers, and significantly advance our knowledge of the pathogenesis and disease progression of many cancer types.

引用

页数：17

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