DIFFERENTIALLY EXPRESSED MicroRNAs IN SMALL CELL LUNG CANCER

被引：119

作者：

Miko, Edit ^{[1
]}

Czimmerer, Zsolt ^{[1
]}

Csanky, Eszter ^{[2
]}

Boros, Gabor ^{[1
]}

Buslig, Julia ^{[1
]}

Dezso, Balazs ^{[3
]}

Scholtz, Beata ^{[1
]}

机构：

[1] Univ Debrecen Med & Hlth Sci Ctr, Dept Biochem & Mol Biol, H-4012 Debrecen, Hungary

[2] Univ Debrecen Med & Hlth Sci Ctr, Pulmonol Clin, H-4012 Debrecen, Hungary

[3] Univ Debrecen Med & Hlth Sci Ctr, Inst Pathol, H-4012 Debrecen, Hungary

来源：

EXPERIMENTAL LUNG RESEARCH | 2009年 / 35卷 / 08期

关键词：

microRNA; small cell lung cancer; GENE-EXPRESSION; NEUROENDOCRINE TUMORS; MICROARRAY ANALYSIS; REDUCED EXPRESSION; RAPID CHANGES; DIAGNOSIS; REPRESSES; SIGNATURE; CARCINOMA; APOPTOSIS;

D O I：

10.3109/01902140902822312

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Expression of microRNAs (miRNAs) is characteristically altered in cancer, and they may play a role in cancer development and progression. The authors performed microarray and real-time quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) analyses to determine the miRNA expression profile of primary small cell lung cancer. Here we show that at least 24 miRNAs are differentially expressed between normal lung and primary small cell lung cancer (SCLC) tumors. These include miR-301, miR-183/96/182, miR-126, and miR-223, which are microRNAs deregulated in other tumor types as well; and other miRNAs, such as miR-374 and miR-210, not previously reported in association with lung cancer. The aberrant miRNA profile of SCLC may offer new insights in the biology of this aggressive tumor, and could potentially provide novel diagnostic markers.

引用

页码：646 / 664

页数：19

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