Directed evolution of microbial oxidative enzymes

被引：15

作者：

Cherry, JR ^{[1
]}

机构：

[1] Novo Nordisk Biotech Inc, Pro Improvement Grp, Davis, CA 95616 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2000年 / 11卷 / 03期

关键词：

D O I：

10.1016/S0958-1669(00)00092-6

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In the past year, a number of oxidative enzymes have been the target of directed evolution. Catalase reaction specificity has been shifted to peroxidase, the high pH, thermal and oxidative stability of a fungal peroxidase has been dramatically improved, and the substrate specificity of cytochrome P450 has been altered to include substrates that the wild-type enzymes are incapable of oxidizing.

引用

页码：250 / 254

页数：5

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