Direct asymmetric three-component organocatalytic anti-selective Mannich reactions in a purely aqueous system

被引：138

作者：

Lili Cheng

Xiaoyu Wu

Yixin Lu

机构：

[1] Natl Univ Singapore, Dept Chem, Singapore 117543, Singapore

[2] Natl Univ Singapore, Med Chem Program, Off Life Sci, Singapore 117543, Singapore

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2007年 / 5卷 / 07期

关键词：

D O I：

10.1039/b701579h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct three-component Mannich reactions of O-benzyl hydroxyacetone with p-anisidine and aromatic or aliphatic aldehydes in the presence of an L-threonine-derived catalyst afforded anti-1,2-amino alcohols in good-to-excellent yields and with enantioselectivities of up to 97%. This study is the first demonstration that direct three-component Mannich reactions can be promoted by a primary amino acid in water.

引用

页码：1018 / 1020

页数：3

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