Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork

被引:427
作者
Hertweck, Christian
Luzhetskyy, Andriy
Rebets, Yuri
Bechthold, Andreas
机构
[1] Univ Freiburg, Inst Pharmazeut Wissensch Pharmazeut Biol & Biote, D-79104 Freiburg, Germany
[2] HKI, Leibniz Inst Nat Prod Res & Infect Biol, D-07745 Jena, Germany
关键词
D O I
10.1039/b507395m
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This review covers advances in understanding of the biosynthesis of polyketides produced by type II PKS systems at the genetic, biochemical and structural levels.
引用
收藏
页码:162 / 190
页数:29
相关论文
共 276 条
[1]   Involvement of AlpV, a new member of the Streptomyces antibiotic regulatory protein family, in regulation of the duplicated type II polyketide synthase alp gene cluster in Streptomyces ambofaciens [J].
Aigle, B ;
Pang, XH ;
Decaris, B ;
Leblond, P .
JOURNAL OF BACTERIOLOGY, 2005, 187 (07) :2491-2500
[2]  
[Anonymous], 2000, Practical Streptomyces genetics, DOI DOI 10.1111/J.1365-2427.2007.01876.X
[3]  
Anson CE, 2000, ANGEW CHEM INT EDIT, V39, P224, DOI 10.1002/(SICI)1521-3773(20000103)39:1<224::AID-ANIE224>3.0.CO
[4]  
2-R
[5]   BENASTATIN-A AND BENASTATIN-B, NEW INHIBITORS OF GLUTATHIONE-S-TRANSFERASE, PRODUCED BY STREPTOMYCES SP MI384-DF12 .1. TAXONOMY, PRODUCTION, ISOLATION, PHYSICOCHEMICAL PROPERTIES AND BIOLOGICAL-ACTIVITIES [J].
AOYAGI, T ;
AOYAMA, T ;
KOJIMA, F ;
MATSUDA, N ;
MARUYAMA, M ;
HAMADA, M ;
TAKEUCHI, T .
JOURNAL OF ANTIBIOTICS, 1992, 45 (09) :1385-1390
[6]   BENASTATIN-C AND BENASTATIN-D, NEW INHIBITORS OF GLUTATHIONE-S-TRANSFERASE, PRODUCED BY STREPTOMYCES SP MI384-DF12 - PRODUCTION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL-ACTIVITIES [J].
AOYAMA, T ;
KOJIMA, F ;
YAMAZAKI, T ;
TATEE, T ;
ABE, F ;
MURAOKA, Y ;
NAGANAWA, H ;
AOYAGI, T ;
TAKEUCHI, T .
JOURNAL OF ANTIBIOTICS, 1993, 46 (05) :712-718
[7]   BEQUINOSTATIN-A AND BEQUINOSTATIN-B, NEW INHIBITORS OF GLUTATHIONE-S-TRANSFERASE, PRODUCED BY STREPTOMYCES SP MI384-DF12 - PRODUCTION, ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL-ACTIVITIES [J].
AOYAMA, T ;
KOJIMA, F ;
ABE, F ;
MURAOKA, Y ;
NAGANAWA, H ;
TAKEUCHI, T ;
AOYAGI, T .
JOURNAL OF ANTIBIOTICS, 1993, 46 (06) :914-920
[8]   Characterization of the pathway-specific positive transcriptional regulator for actinorhodin biosynthesis in Streptomyces coelicolor A3(2) as a DNA-binding protein [J].
Arias, P ;
Fernández-Moreno, MA ;
Malpartida, F .
JOURNAL OF BACTERIOLOGY, 1999, 181 (22) :6958-6968
[9]   Self-malonylation is an intrinsic property of a chemically synthesized type II polyketide synthase acyl carrier protein [J].
Arthur, CJ ;
Szafranska, A ;
Evans, SE ;
Findlow, SC ;
Burston, SG ;
Owen, P ;
Clark-Lewis, I ;
Simpson, TJ ;
Crosby, J ;
Crump, MP .
BIOCHEMISTRY, 2005, 44 (46) :15414-15421
[10]   JADOMYCIN, A NOVEL 8H-BENZ[B]OXAZOLO[3,2-F]PHENANTHRIDINE ANTIBIOTIC FROM STREPTOMYCES-VENEZUELAE ISP5230 [J].
AYER, SW ;
MCINNES, AG ;
THIBAULT, P ;
WALTER, JA ;
DOULL, JL ;
PARNELL, T ;
VINING, LC .
TETRAHEDRON LETTERS, 1991, 32 (44) :6301-6304