Towards building a chromosome segregation machine

被引：54

作者：

Bloom, Kerry ^{[1
]}

Joglekar, Ajit ^{[1
]}

机构：

[1] Univ N Carolina, Dept Biol, Chapel Hill, NC 27599 USA

来源：

NATURE | 2010年 / 463卷 / 7280期

关键词：

SPINDLE ASSEMBLY CHECKPOINT; BUDDING YEAST; KINETOCHORE COMPLEX; MITOTIC SPINDLE; CENTROMERIC NUCLEOSOMES; PERICENTRIC CHROMATIN; STRUCTURAL INTEGRITY; PLASMID PARTITION; DISTINCT PATHWAYS; MICROTUBULE TIPS;

D O I：

10.1038/nature08912

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

All organisms, from bacteria to humans, face the daunting task of replicating, packaging and segregating up to two metres (about 6 x 10(9) base pairs) of DNA when each cell divides. This task is carried out up to a trillion times during the development of a human from a single fertilized cell. The strategy by which DNA is replicated is now well understood. But when it comes to packaging and segregating a genome, the mechanisms are only beginning to be understood and are often as variable as the organisms in which they are studied.

引用

页码：446 / 456

页数：11

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