Simultaneous multimodal imaging with integrated photoacoustic microscopy and optical coherence tomography

被引：90

作者：

Jiao, Shuliang ^{[1
]}

Xie, Zhixing ^{[2
]}

Zhang, Hao F. ^{[2
]}

Puliafito, Carmen A. ^{[1
]}

机构：

[1] Univ So Calif, Dept Ophthalmol, Los Angeles, CA 90033 USA

[2] Univ Wisconsin, Dept Elect Engn & Comp Sci, Milwaukee, WI 53211 USA

来源：

OPTICS LETTERS | 2009年 / 34卷 / 19期

基金：

美国国家卫生研究院;

关键词：

SUBCUTANEOUS STRUCTURES; RESOLUTION;

D O I：

10.1364/OL.34.002961

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

We have developed a multimodal imaging technique by integrating photoacoustic microscopy and spectral-domain optical coherence tomography to provide simultaneous volumetric microscopic imaging of both optical absorption and scattering contrasts in biological tissues. In the integrated system, the two imaging modalities share the same optical scanning and delivery mechanisms after their probing and illumination light beams are combined. By further synchronizing the image acquisitions, the images from the two modalities are intrinsically registered. The capabilities of this novel technique were demonstrated by imaging both the microanatomy and microvasculature in mouse ears in vivo. (C) 2009 Optical Society of America

引用

页码：2961 / 2963

页数：3

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