Neuroprotective Activities of Marine Natural Products from Marine Sponges

被引：18

作者：

Alghazwi, Mousa ^{[1
,2
,3
]}

Kan, Yen Qi ^{[1
,2
]}

Zhang, Wei ^{[1
,2
,4
]}

Gai, Wei Ping ^{[5
,6
]}

Yan, Xiao-Xin ^{[7
,8
]}

机构：

[1] Flinders Univ S Australia, Flinders Ctr Marine Bioprod Dev CMBD, Bedford Pk, SA, Australia

[2] Flinders Univ S Australia, Sch Med, Dept Med Biotechnol, Adelaide, SA 5001, Australia

[3] Minist Higher Educ Saudi Arabia, Riyadh 11153, Saudi Arabia

[4] Shanghai Jiao Tong Univ, Renji Hosp, Ctr Marine Drugs, Shanghai 200240, Peoples R China

[5] Flinders Univ S Australia, Sch Med, Dept Surg, Bedford Pk, SA 5042, Australia

[6] Flinders Univ S Australia, Sch Med, Ctr Neurosci, Bedford Pk, SA 5042, Australia

[7] Cent S Univ, Sch Basic Med, Dept Anat & Neurobiol, Changsha, Hunan, Peoples R China

[8] Key Lab Hunan Prov Neurodegenerat Disorders, Changsha, Hunan, Peoples R China

来源：

CURRENT MEDICINAL CHEMISTRY | 2016年 / 23卷 / 04期

基金：

英国医学研究理事会; 中国国家自然科学基金; 澳大利亚国家健康与医学研究理事会;

关键词：

Acetylcholinesterase; Alzheimer's disease; amyloid beta; marine sponge; natural products; nerve growth factor; neurodegenerative diseases; neuroprotection; oxidative stress; tau protein; BIOACTIVE BROMOPYRROLE ALKALOIDS; NERVE GROWTH-FACTOR; MISCELLANEOUS MECHANISMS; ANTIVIRAL ACTIVITIES; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; IN-VIVO; LIPID-PEROXIDATION; BACE INHIBITORS; PROTEIN-TAU;

D O I：

10.2174/0929867323666151127201249

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

This review covers the compounds isolated from marine sponges with neuroprotective activities during the period between 1999 and 2014 based on their chemical structures, collections sites, sponge taxonomy and neuroprotective effects. These compounds were isolated from marine sponges collected from 18 countries, most of them in Indonesia, followed by Japan. A total of 90 compounds were reported to exhibit a range of neuroprotective efficacy. These compounds were shown to inhibit beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1), modulate the synthesis or activity of some neurotransmitters such as acetylcholinesterase and glutamate, enhancement of serotonin, reducing oxidative stress, inhibition of kinases and proteases, and enhancement of neurite growth. None of them have yet progressed into any marine pharmaceutical development pipeline, therefore sustained researches will be required to enhance the potential of utilizing these compounds in the future for prevention and therapeutic treatment of neurodegenerative diseases.

引用

页码：360 / 382

页数：23

共 112 条

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