Asymmetric bioreductions of β-nitro acrylates as a route to chiral β2-Amino acids

被引：82

作者：

Swiderska, Magdalena A. ^{[1
]}

Stewart, Jon D. ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Gainesville, FL 32611 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 26期

关键词：

D O I：

10.1021/ol062612f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reductions of beta-nitroacrylates by Saccharomyces carlsbergensis old yellow enzyme is the key step in a concise route to optically active beta(2)-amino acids. The enzymatic reductions occur with 87 - 96% ee, with larger substrates providing greater stereoselectivities. This work extends enantioselective enzymatic alkene reductions to include acyclic systems with weakly coordinating substituents.

引用

页码：6131 / 6133

页数：3

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