Photo-Targeted Nanoparticles

被引：109

作者：

Dvir, Tal ^{[1
,2
]}

Banghart, Matthew R. ^{[3
]}

Timko, Brian P. ^{[1
,4
]}

Langer, Robert ^{[2
]}

Kohane, Daniel S. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Childrens Hosp Boston,Div Crit Care Med, Lab Biomat & Drug Delivery,Dept Anesthesiol, Boston, MA 02115 USA

[2] MIT, Dept Chem Engn, Cambridge, MA 02142 USA

[3] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA

[4] Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

来源：

NANO LETTERS | 2010年 / 10卷 / 01期

关键词：

Nanoparticles; cell targeting; caging group; light; drug delivery; CELL MOTILITY; THERAPY; CANCER; DELIVERY; RELEASE; ACTIVATION; LIPOSOMES; KINETICS; RECEPTOR;

D O I：

10.1021/nl903411s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a novel and simple proof-of-concept of a nanoparticulate system that targets any tissue selectively upon illumination. Nanoparticles were covalently functionalized with the amino acid sequence YIGSR, which adheres to the beta 1 integrins present on most cell surfaces, This peptide was masked with a caging group, rendering it biologically inert. Illumination with UV light released the caging group from the YIGSR, allowing binding to cells.

引用

页码：250 / 254

页数：5

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