''Willed action'': A functional MRI study of the human prefrontal cortex during a sensorimotor task

被引:68
作者
Hyder, F
Phelps, EA
Wiggins, CJ
Labar, KS
Blamire, AM
Shulman, RG
机构
[1] YALE UNIV,DEPT PSYCHOL,NEW HAVEN,CT 06510
[2] MAX PLANCK INST NEUROL RES,D-04103 LEIPZIG,GERMANY
[3] JOHN RADCLIFFE HOSP,MRC,OXFORD OX3 9DU,ENGLAND
关键词
positron emission tomography; human brain mapping; dorsolateral prefrontal cortex; verbal fluency; Brodmann areas 6,8,9,24,32,45, and 46);
D O I
10.1073/pnas.94.13.6989
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Functional MRI (fMRI) was used to examine human brain activity within the dorsolateral prefrontal cortex during a sensorimotor task that had been proposed to require selection between several responses, a cognitive concept termed ''willed action'' in a positron emission tomography (PET) study by Frith ct al, [Frith, C. D., Friston, K., Liddle, P. E. & Frackowiak, R. S. J. (1991) Proc, R. Sec. London Ser. B 244, 241-246], We repeated their sensorimotor task, in which the subject chooses to move either of two fingers after a stimulus, by fMRI experiments in a 2.1-T imaging spectrometer, Echo-planar images were acquired from four coronal slices in the prefrontal cortex from nine healthy subjects, Slices were 5 mm thick, centers separated by 7 mm, with nominal in-plane spatial resolution of 9.6 x 5.0 mm(2) for mean data, Our mean results are in agreement with the PET results in that we saw similar bilateral activations, The present results are compared with our previously published fMRI study of a verbal fluency task, which had also been proposed by Frith ct al, to elicit a ''willed action'' response, We find a clear separation of activation foci in the left dorsolateral prefrontal cortex for the sensorimotor (Brodmann area 46) and verbal fluency (Brodmann area 45) tasks, Hence, assigning a particular activated region to ''willed action'' is not supported by the fMRI data when examined closely because identical regions are not activated with different modalities, Similar modality linked activations can be observed in the original PET study but the greater resolution of the fMRI data makes the modality linkages more definite.
引用
收藏
页码:6989 / 6994
页数:6
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