The class A and class B synMuv genes are functionally redundant negative regulators of a Ras signaling pathway that induces C. elegans vulval development. A number of class B synMuv genes encode components of an Rb and histone deacetylase complex that likely acts to repress transcription of genes required for vulval induction. We discovered a new class of synMuv genes that acts redundantly with both the A and B classes of genes in vulval cell-fate determination. These new class C synMuv genes encode TRRAP, MYST family histone acetyltransferase, and Enhancer of Polycomb homologs, which form a putative C. elegrans Tip60/NuA4-like histone acetyltransferase complex. A fourth gene with partial class C synMuv properties encodes a homolog of the mammalian SWI/SNF family ATPase p400. Our findings indicate that the coordinated action of two chromatin-modifying complexes, one with histone deacetylase and the other with histone acetyltransferase activity, is important in regulating Ras signaling and specifying cell fates during C. elegans development.
机构:Penn State Univ, Howard Hughes Med Inst, Althouse Lab 306, University Pk, PA 16802 USA
Brown, CE
Howe, L
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机构:Penn State Univ, Howard Hughes Med Inst, Althouse Lab 306, University Pk, PA 16802 USA
Howe, L
Sousa, K
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机构:Penn State Univ, Howard Hughes Med Inst, Althouse Lab 306, University Pk, PA 16802 USA
Sousa, K
Alley, SC
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机构:Penn State Univ, Howard Hughes Med Inst, Althouse Lab 306, University Pk, PA 16802 USA
Alley, SC
Carrozza, MJ
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机构:Penn State Univ, Howard Hughes Med Inst, Althouse Lab 306, University Pk, PA 16802 USA
Carrozza, MJ
Tan, S
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机构:Penn State Univ, Howard Hughes Med Inst, Althouse Lab 306, University Pk, PA 16802 USA
Tan, S
Workman, JL
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Penn State Univ, Howard Hughes Med Inst, Althouse Lab 306, University Pk, PA 16802 USAPenn State Univ, Howard Hughes Med Inst, Althouse Lab 306, University Pk, PA 16802 USA
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Penn State Univ, Dept Biochem & Mol Biol, Howard Hughes Med Inst, University Pk, PA 16802 USAPenn State Univ, Dept Biochem & Mol Biol, Howard Hughes Med Inst, University Pk, PA 16802 USA
Brown, CE
Lechner, T
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Penn State Univ, Dept Biochem & Mol Biol, Howard Hughes Med Inst, University Pk, PA 16802 USAPenn State Univ, Dept Biochem & Mol Biol, Howard Hughes Med Inst, University Pk, PA 16802 USA
Lechner, T
Howe, L
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Penn State Univ, Dept Biochem & Mol Biol, Howard Hughes Med Inst, University Pk, PA 16802 USAPenn State Univ, Dept Biochem & Mol Biol, Howard Hughes Med Inst, University Pk, PA 16802 USA
Howe, L
Workman, JL
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Penn State Univ, Dept Biochem & Mol Biol, Howard Hughes Med Inst, University Pk, PA 16802 USAPenn State Univ, Dept Biochem & Mol Biol, Howard Hughes Med Inst, University Pk, PA 16802 USA
机构:Penn State Univ, Howard Hughes Med Inst, Althouse Lab 306, University Pk, PA 16802 USA
Brown, CE
Howe, L
论文数: 0引用数: 0
h-index: 0
机构:Penn State Univ, Howard Hughes Med Inst, Althouse Lab 306, University Pk, PA 16802 USA
Howe, L
Sousa, K
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h-index: 0
机构:Penn State Univ, Howard Hughes Med Inst, Althouse Lab 306, University Pk, PA 16802 USA
Sousa, K
Alley, SC
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h-index: 0
机构:Penn State Univ, Howard Hughes Med Inst, Althouse Lab 306, University Pk, PA 16802 USA
Alley, SC
Carrozza, MJ
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h-index: 0
机构:Penn State Univ, Howard Hughes Med Inst, Althouse Lab 306, University Pk, PA 16802 USA
Carrozza, MJ
Tan, S
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h-index: 0
机构:Penn State Univ, Howard Hughes Med Inst, Althouse Lab 306, University Pk, PA 16802 USA
Tan, S
Workman, JL
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h-index: 0
机构:
Penn State Univ, Howard Hughes Med Inst, Althouse Lab 306, University Pk, PA 16802 USAPenn State Univ, Howard Hughes Med Inst, Althouse Lab 306, University Pk, PA 16802 USA
机构:
Penn State Univ, Dept Biochem & Mol Biol, Howard Hughes Med Inst, University Pk, PA 16802 USAPenn State Univ, Dept Biochem & Mol Biol, Howard Hughes Med Inst, University Pk, PA 16802 USA
Brown, CE
Lechner, T
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h-index: 0
机构:
Penn State Univ, Dept Biochem & Mol Biol, Howard Hughes Med Inst, University Pk, PA 16802 USAPenn State Univ, Dept Biochem & Mol Biol, Howard Hughes Med Inst, University Pk, PA 16802 USA
Lechner, T
Howe, L
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h-index: 0
机构:
Penn State Univ, Dept Biochem & Mol Biol, Howard Hughes Med Inst, University Pk, PA 16802 USAPenn State Univ, Dept Biochem & Mol Biol, Howard Hughes Med Inst, University Pk, PA 16802 USA
Howe, L
Workman, JL
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h-index: 0
机构:
Penn State Univ, Dept Biochem & Mol Biol, Howard Hughes Med Inst, University Pk, PA 16802 USAPenn State Univ, Dept Biochem & Mol Biol, Howard Hughes Med Inst, University Pk, PA 16802 USA