pH-sensitive nanoparticles self-assembled from a novel class of biodegradable amphiphilic copolymers based on chitosan

被引：31

作者：

Cai, Guoqiang ^{[1
]}

Jiang, Hongliang ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Polymer Sci & Engn, Hangzhou 310027, Zhejiang, Peoples R China

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2009年 / 20卷 / 06期

基金：

中国国家自然科学基金;

关键词：

POLYMERIC MICELLES; DRUG-DELIVERY; DERIVATIVES; LIGHT; SYSTEMS; DESIGN;

D O I：

10.1007/s10856-008-3689-6

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

A new type of biodegradable amphiphilic graft copolymers, PEG-g-hexanoyl chitosan, was synthesized by a facile scheme. The self-assemble properties of the copolymers were studied by TEM, fluorometry and dynamic light scattering. It was found that spherical nanoparticles of the copolymers could be formed through dialysis method. With the increase of PEG content in the copolymers, the average diameter of the nanoparticles decreased from about 180 to 40 nm. PEG fraction in the copolymers has little effect on the copolymer CAC. The micellization of the copolymers was strongly dependent of the medium pH. When pH was lowered from 7.2 to 6.8, the average diameter of the nanoparticles dramatically changed from about 180 to 60 nm.

引用

收藏

页码：1315 / 1320

页数：6

相关论文

共 19 条

[1]

Synthesis and fungicidal activity of new N,O-acyl chitosan derivatives [J].

Badawy, MEI ;

Rabea, EI ;

Rogge, TM ;

Stevens, CV ;

Smagghe, G ;

Steurbaut, W ;

Höfte, M .

BIOMACROMOLECULES, 2004, 5 (02) :589-595

[2]

Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: Polymeric micelles that are responsive to intracellular pH change [J].

Bae, Y ;

Fukushima, S ;

Harada, A ;

Kataoka, K .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (38) :4640-4643

[3]

Phosphorylcholine-based pH-responsive diblock copolymer micelles as drug delivery vehicles: Light scattering, electron microscopy, and fluorescence experiments [J].

Giacomelli, C ;

Le Men, L ;

Borsali, R ;

Lai-Kee-Him, J ;

Brisson, A ;

Armes, SP ;

Lewis, AL .

BIOMACROMOLECULES, 2006, 7 (03) :817-828

[4]

Synthetic micelle sensitive to IR light via a two-photon process [J].

Goodwin, AP ;

Mynar, JL ;

Ma, YZ ;

Fleming, GR ;

Fréchet, JMJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (28) :9952-9953

[5]

Synthesis and study of water-soluble chitosan-O-poly(ethylene glycol) graft copolymers [J].

Gorochovceva, N ;

Makuska, R .

EUROPEAN POLYMER JOURNAL, 2004, 40 (04) :685-691

[6]

Supramolecular drug-delivery systems based on polymeric core-shell architectures [J].

Haag, R .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (03) :278-282

[7]

Polysaccharide colloidal particles as delivery systems for macromolecules [J].

Janes, KA ;

Calvo, P ;

Alonso, MJ .

ADVANCED DRUG DELIVERY REVIEWS, 2001, 47 (01) :83-97

[8]

A new design for light-breakable polymer micelles [J].

Jiang, JQ ;

Tong, X ;

Zhao, Y .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (23) :8290-8291

[9]

Chitosan chemistry and pharmaceutical perspectives [J].

Kumar, MNVR ;

Muzzarelli, RAA ;

Muzzarelli, C ;

Sashiwa, H ;

Domb, AJ .

CHEMICAL REVIEWS, 2004, 104 (12) :6017-6084

[10]

Polymeric micelles as new drug carriers [J].

Kwon, GS ;

Okano, T .

ADVANCED DRUG DELIVERY REVIEWS, 1996, 21 (02) :107-116