Extended-spectrum β-lactamase-producing Escherichia coli in Spain belong to a large variety of multilocus sequence typing types, including ST10 complex/A, ST23 complex/A and ST131/B2

被引：152

作者：

Oteo, Jesus ^{[1
]}

Diestra, Karol ^{[2
]}

Juan, Carlos ^{[3
]}

Bautista, Veronica ^{[1
]}

Novais, Angela ^{[4
,5
]}

Perez-Vazquez, Maria ^{[1
]}

Moya, Bartolome ^{[3
]}

Miro, Elisenda ^{[2
]}

Coque, Teresa M. ^{[4
,5
]}

Oliver, Antonio ^{[3
]}

Canton, Rafael ^{[4
,5
]}

Navarro, Ferran ^{[2
]}

Campos, Jose ^{[1
]}

机构：

[1] Ctr Nacl Microbiol Virol & Inmunol Sanitarias Maja, Inst Salud Carlos III, Serv Bacteriol, Lab Antibiot, Madrid 28220, Spain

[2] Hosp Santa Creu & Sant Pau, Microbiol Serv, Barcelona, Spain

[3] Hosp Son Dureta, Microbiol Serv, Palma de Mallorca, Spain

[4] Hosp Univ Ramon & Cajal, Microbiol Serv, CIBERESP, Madrid, Spain

[5] CSIC, Unidad Resistencia Antibiot & Virulencia Bacteria, Madrid, Spain

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2009年 / 34卷 / 02期

关键词：

ESBL; MLST; Escherichia coli; Phylogenetic group; KLEBSIELLA-PNEUMONIAE; CLONE; PREVALENCE; PLASMIDS; CTX-M-15; STRAINS; SPREAD; DISSEMINATION; BLA(CTX-M-9); RESISTANCE;

D O I：

10.1016/j.ijantimicag.2009.03.006

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In this study, we investigated the population structure of extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in Spain and determined possible associations between specific multilocus sequence typing (MLST) types and ESBL types. Ninety-two ESBL-producing E. coli isolates from 11 Spanish hospitals were studied. The predominant ESBLs in this collection were CTX-M-14 (45.7%), SHV-12 (21.7%) and CTX-M-9 (20.6%). Phylogenetic groups and MLST types were studied. Thirty-seven isolates (40.2%) belonged to phylogroup A, 26 (28.3%) to group B1, 13 (14.1%) to group B2 and 16 (17.4%) to group D. Fifty-six sequence types (STs) were identified, but ST131 (eight isolates) and ST167 (five isolates) were the most prevalent. The most common ST complexeswere ST10 (13 isolates; 14.3%) and ST23 (10 isolates; 11%). Escherichia coli ST131 carried six different ESBLs (CTX-M-1, CTX-M-9, CTX-M-10, CTX-M-14, CTX-M-15 and SHV-12), E. coli ST10 complex carried five ESBLs and E. coli ST23 complex carried four ESBLs. A great diversity of MLST types was observed among Spanish ESBL- producing E. coli isolates. (C) 2009 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：173 / 176

页数：4

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