Gastric Cancer: Descriptive Epidemiology, Risk Factors, Screening, and Prevention

被引：1820

作者：

Karimi, Parisa ^{[1
]}

Islami, Farhad ^{[4
,6
]}

Anandasabapathy, Sharmila ^{[5
]}

Freedman, Neal D. ^{[3
]}

Kamangar, Farin ^{[2
,6
]}

机构：

[1] Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 21251 USA

[2] Morgan State Univ, Dept Publ Hlth Anal, Sch Community Hlth & Policy, Baltimore, MD 21251 USA

[3] NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA

[4] Mt Sinai Med Ctr, Mt Sinai Sch Med, Inst Transit Epidemiol, New York, NY 10029 USA

[5] Mt Sinai Med Ctr, Dept Med, Div Gastroenterol, New York, NY 10029 USA

[6] Univ Tehran Med Sci, Digest Dis Res Inst, Digest Oncol Res Ctr, Tehran, Iran

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2014年 / 23卷 / 05期

关键词：

HELICOBACTER-PYLORI INFECTION; BODY-MASS INDEX; GASTROESOPHAGEAL-REFLUX DISEASE; PACIFIC CONSENSUS GUIDELINES; GENOME-WIDE ASSOCIATION; 2 DISTINCT ETIOLOGIES; STOMACH-CANCER; PHYSICAL-ACTIVITY; UNITED-STATES; REDUCED RISK;

D O I：

10.1158/1055-9965.EPI-13-1057

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Less than a century ago, gastric cancer was the most common cancer in the United States and perhaps throughout the world. Despite its worldwide decline in incidence over the past century, gastric cancer remains a major killer across the globe. This article reviews the epidemiology, screening, and prevention of gastric cancer. We first discuss the descriptive epidemiology of gastric cancer, including its incidence, survival, mortality, and trends over time. Next, we characterize the risk factors for gastric cancer, both environmental and genetic. Serologic markers and histological precursor lesions of gastric cancer and early detection of gastric cancer using these markers are reviewed. Finally, we discuss prevention strategies and provide suggestions for further research. (C) 2014 AACR.

引用

页码：700 / 713

页数：14

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