Non-coding RNAs in the nervous system

被引:134
作者
Mehler, Mark F.
Mattick, John S. [1 ]
机构
[1] Univ Queensland, Inst Mol Biosci, ARC Special Res Ctr Funct & Appl Genomics, St Lucia, Qld 4072, Australia
[2] Yeshiva Univ Albert Einstein Coll Med, Rose F Kennedy Ctr Res Mental Retardat & Dev Disa, Bronx, NY 10461 USA
[3] Yeshiva Univ Albert Einstein Coll Med, Inst Brain Disorders & Neural Regenerat, Albert Einstein Canc Ctr, Dept Psychiat & Behav, Bronx, NY 10461 USA
[4] Yeshiva Univ Albert Einstein Coll Med, Dept Neurol, Albert Einstein Canc Ctr, Inst Brain Disorders & Neural Regenerat, Bronx, NY 10461 USA
[5] Yeshiva Univ Albert Einstein Coll Med, Dept Neurosci, Albert Einstein Canc Ctr, Inst Brain Disorders & Neural Regenerat, Bronx, NY 10461 USA
来源
JOURNAL OF PHYSIOLOGY-LONDON | 2006年 / 575卷 / 02期
关键词
D O I
10.1113/jphysiol.2006.113191
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Increasing evidence suggests that the development and function of the nervous system is heavily dependent on RNA editing and the intricate spatiotemporal expression of a wide repertoire of non-coding RNAs, including micro RNAs, small nucleolar RNAs and longer non-coding RNAs. Non-coding RNAs may provide the key to understanding the multi-tiered links between neural development, nervous system function, and neurological diseases.
引用
收藏
页码:333 / 341
页数:9
相关论文
共 141 条
[121]   Contextual fear conditioning regulates the expression of brain-specific small nucleolar RNAs in hippocampus [J].
Rogelj, B ;
Hartmann, CEA ;
Yeo, CH ;
Hunt, SP ;
Giese, KP .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2003, 18 (11) :3089-3096
[122]   Small non-coding RNAs and genomic imprinting [J].
Royo, H. ;
Bortolin, M. -L. ;
Seitz, H. ;
Cavaille, J. .
CYTOGENETIC AND GENOME RESEARCH, 2006, 113 (1-4) :99-108
[123]   The RNA binding protein FMRP: new connections and missing links [J].
Schaeffer, C ;
Beaulande, M ;
Ehresmann, C ;
Ehresmann, B ;
Moine, H .
BIOLOGY OF THE CELL, 2003, 95 (3-4) :221-228
[124]   A brain-specific microRNA regulates dendritic spine development [J].
Schratt, GM ;
Tuebing, F ;
Nigh, EA ;
Kane, CG ;
Sabatini, ME ;
Kiebler, M ;
Greenberg, ME .
NATURE, 2006, 439 (7074) :283-289
[125]   A large imprinted microRNA gene cluster at the mouse Dlkl-Gtl2 domain [J].
Seitz, H ;
Royo, H ;
Bortolin, ML ;
Lin, SP ;
Ferguson-Smith, AC ;
Cavaillé, J .
GENOME RESEARCH, 2004, 14 (09) :1741-1748
[126]   Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation [J].
Sempere, LF ;
Freemantle, S ;
Pitha-Rowe, I ;
Moss, E ;
Dmitrovsky, E ;
Ambros, V .
GENOME BIOLOGY, 2004, 5 (03)
[127]   Molecular cloning and expression analysis of a novel gene DGCR8 located in the DiGeorge syndrome chromosomal region [J].
Shiohama, A ;
Sasaki, T ;
Noda, S ;
Minoshima, S ;
Shimizu, N .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 304 (01) :184-190
[128]   The uniqueness of the imprinting mechanism [J].
Sleutels, F ;
Barlow, DP ;
Lyle, R .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2000, 10 (02) :229-233
[129]   Regulation of miRNA expression during neural cell specification [J].
Smirnova, L ;
Gräfe, A ;
Seiler, A ;
Schumacher, S ;
Nitsch, R ;
Wulczyn, FG .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2005, 21 (06) :1469-1477
[130]   RNA editing by ADARs is important for normal behavior in Caenorhabditis elegans [J].
Tonkin, LA ;
Saccomanno, L ;
Morse, DP ;
Brodigan, T ;
Krause, M ;
Bass, BL .
EMBO JOURNAL, 2002, 21 (22) :6025-6035