Small non-coding RNAs and genomic imprinting

被引：51

作者：

Royo, H.

Bortolin, M. -L.

Seitz, H.

Cavaille, J.

机构：

[1] CNRS, UMR 5099, LBME, IFR 109, FR-31062 Toulouse, France

[2] UMMS, Dept Biochem & Mol Pharmacol, Worcester, MA USA

来源：

CYTOGENETIC AND GENOME RESEARCH | 2006年 / 113卷 / 1-4期

关键词：

D O I：

10.1159/000090820

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Experimental and computer-assisted approaches have led to the identification of hundreds of imprinted small RNA genes, mainly clustered in two chromosomal domains (human 15q1 1 -> q13 and 14q32 loci). The genes are only detected in placental mammals and belong to the C/D RNA and microRNA gene families. These are small non-coding RNAs involved in RNA-guided post-transcriptional RNA modifications and RNA-mediated gene silencing, respectively. Here, we discuss their potential functions and report the identification of novel small RNA genes lying within (or nearby) known imprinted chromosomal domains. Copyright (c) 2006 S. Karger AG, Basel.

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收藏

页码：99 / 108

页数：10

相关论文

共 74 条

[1] RNA silencing and genome regulation [J].

Almeida, R ;

Allshire, RC .

TRENDS IN CELL BIOLOGY, 2005, 15 (05) :251-258

[2] Clustering and conservation patterns of human microRNAs [J].

Altuvia, Y ;

Landgraf, P ;

Lithwick, G ;

Elefant, N ;

Pfeffer, S ;

Aravin, A ;

Brownstein, MJ ;

Tuschl, T ;

Margalit, H .

NUCLEIC ACIDS RESEARCH, 2005, 33 (08) :2697-2706

[3] The functions of animal microRNAs [J].

Ambros, V .

NATURE, 2004, 431 (7006) :350-355

[4] Regulation of flowering time and floral organ identity by a microRNA and its APETALA2-like target genes [J].

Aukerman, MJ ;

Sakai, H .

PLANT CELL, 2003, 15 (11) :2730-2741

[5] The expanding snoRNA world [J].

Bachellerie, JP ;

Cavaillé, J ;

Hüttenhofer, A .

BIOCHIMIE, 2002, 84 (08) :775-790

[6] MicroRNA binding sites in Arabidopsis class IIIHD-ZIP mRNAs are required for methylation of the template chromosome [J].

Bao, N ;

Lye, KW ;

Barton, MK .

DEVELOPMENTAL CELL, 2004, 7 (05) :653-662

[7] Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs [J].

Bartel, DP ;

Chen, CZ .

NATURE REVIEWS GENETICS, 2004, 5 (05) :396-400

[8] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[9] Identification of hundreds of conserved and nonconserved human microRNAs [J].

Bentwich, I ;

Avniel, A ;

Karov, Y ;

Aharonov, R ;

Gilad, S ;

Barad, O ;

Barzilai, A ;

Einat, P ;

Einav, U ;

Meiri, E ;

Sharon, E ;

Spector, Y ;

Bentwich, Z .

NATURE GENETICS, 2005, 37 (07) :766-770

[10] Phylogenetic shadowing and computational identification of human microRNA genes [J].

Berezikov, E ;

Guryev, V ;

van de Belt, J ;

Wienholds, E ;

Plasterk, RHA ;

Cuppen, E .

CELL, 2005, 120 (01) :21-24

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