Clean and efficient synthesis of azo dyes using polymer-supported reagents

被引：47

作者：

Caldarelli, M

Baxendale, IR

Ley, SV

机构：

[1] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[2] Pharmacia & Uphohn, Dept Chem, I-20014 Milan, Italy

来源：

GREEN CHEMISTRY | 2000年 / 2卷 / 02期

关键词：

D O I：

10.1039/b000816h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The recent technological advancements in polymer-supported reactions have led to the propagation of combinatorial chemistry as a method for the rapid and efficient preparation of novel functionalised molecules. An interesting and fast growing branch of this area is polymer-supported reagents. Here we describe the principles of generating diazonium salts and their coupling using polymer-supported reagents and sequestrating agents, to form azo dyes in a clean manner.

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页码：43 / 45

页数：3

相关论文

共 19 条

[1] Development of a polymer bound Wittig reaction and use in multi-step organic synthesis for the overall conversion of alcohols to β-hydroxyamines [J].

Bolli, MH ;

Ley, SV .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1998, (15) :2243-2246

[2] Synthesis of an array of potential matrix metalloproteinase inhibitors using a sequence of polymer-supported reagents [J].

Caldarelli, M ;

Habermann, J ;

Ley, SV .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1999, 9 (14) :2049-2052

[3] Clean five-step synthesis of an array of 1,2,3,4-tetra-substituted pyrroles using polymer-supported reagents [J].

Caldarelli, M ;

Habermann, J ;

Ley, SV .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1999, (02) :107-110

[4] A new scavenger resin for amines [J].

Coppola, GM .

TETRAHEDRON LETTERS, 1998, 39 (45) :8233-8236

[5]

Gordon, 1998, COMBINATORIAL CHEM M

[6] Clean synthesis of α-bromo ketones and their utilisation in the synthesis of 2-alkoxy-2,3-dihydro-2-aryl-1,4-benzodioxanes, 2-amino-4-aryl-1,3-thiazoles and piperidino-2-amino-1,3-thiazoles using polymer-supported reagents [J].

Habermann, J ;

Ley, SV ;

Scicinski, JJ ;

Scott, JS ;

Smits, R ;

Thomas, AW .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1999, (17) :2425-2427

[7] Three-step synthesis of an array of substituted benzofurans using polymer-supported reagents [J].

Habermann, J ;

Ley, SV ;

Smits, R .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1999, (17) :2421-2423

[8] Synthesis of the potent analgesic compound (±)-epibatidine using an orchestrated multi-step sequence of polymer supported reagents [J].

Habermann, J ;

Ley, SV ;

Scott, JS .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1999, (10) :1253-1255

[9] Clean six-step synthesis of a piperidino-thiomorpholine library using polymer-supported reagents [J].

Habermann, J ;

Ley, SV ;

Scott, JS .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1998, (19) :3127-3130

[10] Clean three-step synthesis of 4,5-dihydro-1H-pyrazoles starting from alcohols using polymer supported reagents [J].

Haunert, F ;

Bolli, MH ;

Hinzen, B ;

Ley, SV .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1998, (15) :2235-2237