Toward a library synthesis of the natural dipeptide antibiotic TAN 1057 A,B

被引：8

作者：

Aguilar, N ^{[1
]}

Krüger, J ^{[1
]}

机构：

[1] Bayer AG, Business Grp Pharma, D-42096 Wuppertal, Germany

来源：

MOLECULES | 2002年 / 7卷 / 06期

关键词：

TAN; 1057; A; B; dipeptide antibiotics; combinatorial chemistry;

D O I：

10.3390/70600469

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The natural dipeptide antibiotic TAN 1057 A,B represents a promising new antibiotic entity. In this communication we report a novel approach for the synthesis of TAN 1057 A,B analogs bearing variations in the .-arginine side chain. This approach involves a combination of liquid and solid phase methods and allows for a library synthesis of analogs of the natural product.

引用

页码：469 / 474

页数：6

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