Application of fungi as biocatalysts for the reduction of diethyl 1-oxoalkylphosphonates in anhydrous hexane

被引：19

作者：

Brzezinska-Rodak, M ^{[1
]}

Zymanczyk-Duda, E ^{[1
]}

Kafarski, P ^{[1
]}

Lejczak, B ^{[1
]}

机构：

[1] Wroclaw Univ Technol, Inst Organ Chem Biochem & Biotechnol, PL-50370 Wroclaw, Poland

来源：

BIOTECHNOLOGY PROGRESS | 2002年 / 18卷 / 06期

关键词：

D O I：

10.1021/bp0200090

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Five different species of microorganisms, namely, Rhodotorula rubra, Rhodotorula glutinis, Cladosporium sp., Verticillium sp., and baker's yeast, turned out to be useful biocatalysts for enantioselective reduction of a variety of diethyl 1-oxoalkylphosphonates. To suppress substrate decomposition, bioreductions were carried out under anhydrous conditions, using lyophilized cells immobilized on Celite R 630. The influence of reaction conditions such as biotransformation time and chemical additives on the. yield of the reaction is discussed.

引用

页码：1287 / 1291

页数：5

共 31 条

[1] Asymmetric bioreduction of racemic 5,4,7,8-tetrahydro-8-methyl-1,3-dimethoxynaphthalen-6-one to the corresponding chiral β-tetralols [J].

Aina, G ;

Nasini, G ;

de Pava, OV .

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2001, 11 (4-6) :367-371

[2] Bioreduction of aromatic ketones: preparation of chiral benzyl alcohols in both enantiomeric forms [J].

Barbieri, C ;

Bossi, L ;

D'Arrigo, P ;

Fantoni, GP ;

Servi, S .

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2001, 11 (4-6) :415-421

[3] Baker's yeast reduction of α-alkyl-α-hydroxy-β-keto esters [J].

Buisson, D ;

Baucherel, X ;

Levoirier, E ;

Juge, S .

TETRAHEDRON LETTERS, 2000, 41 (09) :1389-1392

[4]

Darrigo P, 1997, ADV APPL MICROBIOL, V44, P81, DOI 10.1016/S0065-2164(08)70460-X

[5] (R)-(+) and (S)-(-) ethyl 4,4,4-trifluoro-3-hydroxy butanoate by enantioselective Baker's yeast reduction [J].

Davoli, P ;

Forni, A ;

Moretti, I ;

Prati, F ;

Torre, G .

ENZYME AND MICROBIAL TECHNOLOGY, 1999, 25 (1-2) :149-152

[6]

DESMET MJ, 1983, ENZYME MICROB TECH, V5, P359

[7] SYNTHESIS OF 1,2-EPOXYOCTANE BY PSEUDOMONAS-OLEOVORANS DURING GROWTH IN A 2-PHASE SYSTEM CONTAINING HIGH-CONCENTRATIONS OF 1-OCTENE [J].

DESMET, MJ ;

WYNBERG, H ;

WITHOLT, B .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1981, 42 (05) :811-816

[8] BIOCONVERSION OF N-OCTANE TO OCTANOIC-ACID BY A RECOMBINANT ESCHERICHIA-COLI CULTURED IN A 2-LIQUID PHASE BIOREACTOR [J].

FAVREBULLE, O ;

SCHOUTEN, T ;

KINGMA, J ;

WITHOLT, B .

BIO-TECHNOLOGY, 1991, 9 (04) :367-371

[9] Effect of additives on the bioreduction of 2-chloro-1-phenyl-2-propen-1-one by baker's yeast [J].

Filho, EPS ;

Rodrigues, JAR ;

Moran, PJS .

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2001, 15 (1-3) :23-28

[10] New approach to diethyl 2-aminoalkylphosphonates [J].

Gajda, T ;

Nowalinska, M ;

Zawadzki, S ;

Zwierzak, A .

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1995, 105 (1-4) :45-50

← 1 2 3 4 →