Sequential one-pot bimetallic Ir(III)/Pd(0) catalysed mono-/bis-alkylation and spirocyclisation processes of 1,3-dimethylbarbituric acid and allenes

被引:67
作者
Lofberg, Christian
Grigg, Ronald [1 ]
Keep, Ann
Derrick, Andrew
Sridharan, Visuvanathar
Kilner, Colin
机构
[1] Univ Leeds, Sch Chem, MIDAS Ctr, Leeds LS2 9JT, W Yorkshire, England
[2] Johnson Matthey, Royston SG8 5HE, Herts, England
[3] Pfizer Ltd, Sandwich CT13 9NJ, Kent, England
关键词
D O I
10.1039/b614098j
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Microwave assisted indirect functionalization of alcohols with 1,3-dimethylbarbituric acid followed by spirocyclisation employing a sequential one-pot Ir(III)/Pd(O) catalysed process, involving the formation of three new C-C bonds, one spirocyclic ring and one di- or tri-substituted exocyclic alkene, is described.
引用
收藏
页码:5000 / 5002
页数:3
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