The effect of age on the B-Cell repertoire

被引:139
作者
Weksler, ME [1 ]
Szabo, P [1 ]
机构
[1] Cornell Univ, Weill Med Coll, New York, NY 10021 USA
关键词
aging; B cells; B cell repertoire; clonal B cell expansions;
D O I
10.1023/A:1006659401385
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The antibody repertoire changes with age. This change reflects, in part, the age-associated impairment in the production of a diverse population of naive B cells in the bone marrow and, in parr, by the decreased diversification of B cells in the germinal center where affinity maturation and isotype switching takes place. B cell number is strictly regulated and despite the decreased output of B cells by the bone marrow does not decline during aging. Self-renewal of peripheral B cells is sufficient to assure the stability of peripheral B cell number. However, when B cell production is stressed as, for example, Following drug-induced lymphopenia, the rate of recovery of B cell number as well as of B cell diversity is compromised in old compared to young mice. Finally, aging is associated with the appearance of B cell clonal expansions which not only limit the diversity of the B cell repertoire but very likely give rise to monoclonal serum immunoglobulins and B cell neoplasms.
引用
收藏
页码:240 / 249
页数:10
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