Manganese-Catalyzed Oxidative Cross-Coupling of Grignard Reagents with Oxygen as an Oxidant

被引：55

作者：

Cahiez, Gerard ^{[1
]}

Duplais, Christophe ^{[1
]}

Buendia, Julien ^{[1
]}

机构：

[1] Univ Paris 13, CNRS, Dept Chem, F-93017 Bobigny, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 36期

关键词：

cross-coupling; Grignard reagents; manganese; oxidation; synthetic methods; REDUCTIVE ELIMINATION; ORGANOMANGANESE REAGENTS; ORGANOMAGNESIUM REAGENTS; HETEROCYCLIC CHLORIDES; BIARYL SYNTHESIS; ALKENYL HALIDES; ARYL HALIDES; COMPLEXES; ARYLATION; KETONES;

D O I：

10.1002/anie.200902188

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Oxidative heterocoupling between two Grignard reagents RMgX and R′MgX is made possible by manganese catalysis with O2 as an oxidant. This procedure, development of which was based on mechanistic analysis of the corresponding homocoupling reaction, can be steered towards the heterocoupling product at the expense of the homocoupling products by judicious choice of the R and R′ groups (see examples). © 2009 Wiley-VCH Verlag GmbH & Co. KCaA.

引用

页码：6731 / 6734

页数：4

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