The influence of small oligosaccharides on the immune system

被引：108

作者：

Bland, EJ ^{[1
]}

Keshavarz, T ^{[1
]}

Bucke, C ^{[1
]}

机构：

[1] Univ Westminster, Sch Biosci, Carbohydrate Res Grp, London W1W 6UW, England

来源：

CARBOHYDRATE RESEARCH | 2004年 / 339卷 / 10期

关键词：

immunomodulation; oligosaccharides; carbohydrates; reactive oxygen species; reactive oxidising species; 2; 7 '-dichlorodihydrofluorescein diacetate;

D O I：

10.1016/j.carres.2004.05.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

In this study, oligosaccharides known to enhance the synthesis of penicillin by Penicillium chrysogenum have been presented to human immune cells and their effect measured. In addition a range of commercially available oligosaccharides have been tested. Results obtained indicate that oligosaccharides with a degree of polymerisation greater than 6 and with a tendency to form helical structures are most effective at influencing the immune system as measured by the production of reactive oxidising species. Laminariheptaose has been shown to increase reactive oxidising species production by up to 25%, whilst mannan-oligosaccharides with a DP of 6 to 7 decrease production by up to 44%. These and other results show that the immune system can recognise subtle differences in oligosaccharides and that these oligosaccharides could potentially be used to modulate the immune response. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：1673 / 1678

页数：6

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